Research aims

How will the capacity of solving a problem in creatures be brought about? This is a tough question that has been studied so far by scientific minds of every different period since ancient Greek times. Tackling the question as basic science, we expect to deepen understanding of human being itself, and to contribute toward technological innovation of new design for human-friendly interface to machines and robots.

We select single-celled organisms as main research object in order to evaluate high ability for information processing by experiment, and we elucidate the mechanism from a dynamical system point of view. Our research strategy is that, by using an advantage of simple organization of body, we describe behavioral intelligence of creature in terms of physical equations of motion. It is an exploration to an origin of organismic intelligence. To do that, we like to use theories, experiments and field works, based on biology, mathematics, physics and information science.

Research interests

Recent publications


  • Schenz,D., Shima, Y., Kuroda,S., Nakagaki,T., Ueda,K., "A Mathematical Model for Adaptive Vein Formation during Exploratory Migration of Physarum polycephalum: Routing while Scouting", J. Phys. D: Appl. Phys 50: 404001 (14pp) (2017.9.28)
  • Kunita, I., Ueda,K., Akita,D., Kuroda,S., Nakagaki,T., "Behavioural differentiation induced by environmental variation when crossing a toxic zone in an amoeba", J. Phys. D: Appl. Phys 50: 354002 (15pp) (2017.8.7)
  • Akita,D.,Schenz,D.,Kuroda,S.,Sato,K.,Ueda,K.,Nakagaki,T., "Current reinforcement model reproduces centre-in-centre vein trajectory of Physarum polycephalum", Development, Growth & Differentiation, DOI:10.1111/dgd.12384, (2017.7.13)
  • Kuroda,S., Takagi,S., Saegusa,T., Nakagaki,T., "Physical ethology of unicellular organism", In Brain Evolution by Design (eds. Shigeno,S., Murakami,Y. N2omura,T) (Springer, New York) (2017.2.17)
  • 2016

  • Akita,D., Kunita, I. Fricker, M. D., Kuroda, S., Sato, K., Nakagaki,T., "Experimental models for Murray's Law", J. Phys. D: Appl. Phys., 50, 024001 (2016.12.2)
  • Kunita,I., Yamaguchi,T., Tero,A., Akiyama,M., Kuroda,S., Nakagaki,Y., " A ciliate memorizes the geometry of a swimming arena", J. R. Soc. Interface 13: 20160155 (2016)
  • Selevted publication

  • Kunita,I., Kuroda,S., Ohki,K., Nakagaki,T., (2014) Attempts to retreat from a dead-ended long capillary by backward swimming in Paramecium, Frontiers in microbiology, 5, 270, doi:10.3389/fmicb.2014.00270
  • Tanaka,Y. Ito,K. Nakagaki,T. Kobayashi,R. J R Soc Interface 9(2012) 222-233.
  • A. Tero, S. Takagi, T. Saigusa, K. Ito, D. P. Bebber, M. D. Fricker, K. Yumiki, R. Kobayashi and T. Nakagaki : “Rules for biologically-inspired adaptive network design”, Science, 327 : 439-442 (2010)
  • Kenji Matsumoto, Seiji Takagi and Toshiyuki Nakagaki : "Locomotive Mechanism of Physarum Plasmodia based on Spatiotemporal Analysis of Protoplasmic Streaming", Biophysical Journal, Vol. 94, 2492-2504 (2008)
  • Seiji Takagi, Yasumasa Nishiura, Toshiyuki Nakagaki, Tetsuo Ueda, Kei-ichi Ueda: “Indecisive behavior of amoeba crossing an environmental barrier”, Proceedings of Int. Symp. On Topological Aspects of Critical Systems and Networks (World Scientific Publishing Co.), 86-93 (2007)
  • Atsushi Tero, Ryo Kobayashi and Toshiyuki Nakagaki: “Mathematical model for adaptive transport network in path finding by true slime mold”, Journal of Theoretical Biology, Vol. 244, 553-564 (2007)
  • Toshiyuki Nakagaki, Hiroyasu Yamada and A’gota To’th: “Maze-solving by an amoeboid organism”Nature Vol.407 (2000), 470